CLINICAL AND GENOMIC CHARACTERIZATION OF CHEMORADIATION-RESISTANT HPV-POSITIVE OROPHARYNGEAL SQUAMOUS CELL CARCINOMA

Clinical and genomic characterization of chemoradiation-resistant HPV-positive oropharyngeal squamous cell carcinoma

IntroductionMost patients with HPV-positive oropharyngeal squamous cell carcinoma (OPSCC) have an excellent response to chemoradiation, and trials are now investigating de-escalated treatment.However, up to 25% of patients with HPV-positive OPSCC will experience recurrence, and up to 5% will even progress through primary treatment.Currently, there

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Gust Alleviation of a Large Aircraft with a Passive Twist Wingtip

This paper presents an investigation into the gust response and wing structure load alleviation of a 200-seater aircraft by employing a passive twist wingtip (PTWT).The research was divided into three stages.The first stage was the design and analysis of the baseline aircraft, including aerodynamic analysis, structural design using the finite eleme

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exploding cluster dynamics probed by XUV fluorescence

Clusters excited by intense laser pulses are a unique source of warm dense matter, that has been the subject of intensive experimental studies.The majority of these hot wheels octo car wash investigations concern atomic clusters, whereas the evolution of molecular clusters excited by intense laser pulses is less explored.In this work we trace the d

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